Pulmonary kinematics from hyperpolarized helium-3 tagged magnetic resonance imaging


Journal Article

Recent innovations in hyperpolarized Helium-3 magnetic resonance imaging (MRI) include the employment of MR tagging techniques for assessment of pulmonary deformation. Historically, such tagging methods have been successfully applied to cardiac research inspiring the development of computational techniques for the quantitative analysis of myocardial deformation. We present related research which concerns the calculation of kinematic quantities, such as displacement and strain, in the lung. Utilizing the high contrast tag lines as landmarks in the images and a recently developed fast n-D B-spline approximation algorithm, we fit a parametric object to the sparse tag line data to smoothly interpolate the underlying deformation field and, subsequently, extract lung kinematic information. We present results from a single human volunteer. © 2007 IEEE.

Full Text

Duke Authors

Cited Authors

  • Tustison, NJ; Altes, TA; Gee, JC; Cai, J; De Lange, EE; Mugler, JP

Published Date

  • November 27, 2007

Published In

  • 2007 4th Ieee International Symposium on Biomedical Imaging: From Nano to Macro Proceedings

Start / End Page

  • 368 - 371

Digital Object Identifier (DOI)

  • 10.1109/ISBI.2007.356865

Citation Source

  • Scopus