Polymyositis after propylthiouracil treatment for hyperthyroidism.


Journal Article

An additional disorder in the spectrum of thyroid related muscle disease is presented. Hypothyroid and hyperthyroid disease are both associated with a variety of muscle abnormalities, from myalgias to myopathy. Polymyositis, however, has never been reported immediately after treatment for active hyperthyroidism. A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day). Electromyography, muscle biopsy, and the course of the patient's illness were consistent with polymyositis. Whether this represents a cause-effect association or a chance occurrence is unknown. Physician awareness of the occurrence of a variety of muscle disorders including polymyositis in thyroid disease is emphasised. A brief discussion of thyroid myopathy, thionamide drug reactions, and polymyositis is included.

Full Text

Duke Authors

Cited Authors

  • Shergy, WJ; Caldwell, DS

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 47 / 4

Start / End Page

  • 340 - 343

PubMed ID

  • 3365032

Pubmed Central ID

  • 3365032

International Standard Serial Number (ISSN)

  • 0003-4967

Digital Object Identifier (DOI)

  • 10.1136/ard.47.4.340


  • eng

Conference Location

  • England