Gonad morphogenesis in vertebrates: divergent means to a convergent end.

Published

Journal Article (Review)

A critical element of successful sexual reproduction is the generation of sexually dimorphic adult reproductive organs, the testis and ovary, which produce functional gametes. Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved. We highlight the mechanisms used by different vertebrate model systems to generate the somatic architecture necessary to support gametogenesis. In addition, we examine the different vertebrate patterns of germ cell migration from their site of origin to colonize the gonad and highlight their roles in sex-specific morphogenesis. We also discuss the plasticity of the adult gonad and consider how different genetic and environmental conditions can induce transitions between testis and ovary morphology.

Full Text

Duke Authors

Cited Authors

  • DeFalco, T; Capel, B

Published Date

  • 2009

Published In

Volume / Issue

  • 25 /

Start / End Page

  • 457 - 482

PubMed ID

  • 19807280

Pubmed Central ID

  • 19807280

Electronic International Standard Serial Number (EISSN)

  • 1530-8995

Digital Object Identifier (DOI)

  • 10.1146/annurev.cellbio.042308.13350

Language

  • eng

Conference Location

  • United States