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Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.

Publication ,  Journal Article
Kozubowski, L; Aboobakar, EF; Cardenas, ME; Heitman, J
Published in: Eukaryot Cell
November 2011

Calcineurin is a calcium-calmodulin-activated serine/threonine-specific phosphatase that operates during cellular responses to stress and plays a prominent role in transcriptional control, whereas regulatory events beyond transcription are less well characterized. This study reveals a novel transcription-independent role of calcineurin during the temperature stress response in the human fungal pathogen Cryptococcus neoformans. The diffusely cytoplasmic calcineurin catalytic subunit Cna1 relocates to endoplasmic reticulum (ER)-associated puncta and the mother-bud neck when cells are subjected to 37°C. More than 50% of Cna1 puncta contain the P-body constituent decapping enzyme Dcp1 and the stress granule constituent poly(A)-binding protein Pub1. These results support a model in which calcineurin orchestrates thermal stress responses by associating with sites of mRNA processing.

Duke Scholars

Published In

Eukaryot Cell

DOI

EISSN

1535-9786

Publication Date

November 2011

Volume

10

Issue

11

Start / End Page

1396 / 1402

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Stress, Physiological
  • Poly(A)-Binding Proteins
  • Microbiology
  • Hot Temperature
  • Gene Expression Regulation, Fungal
  • Endoplasmic Reticulum
  • Endopeptidases
  • Cytoplasmic Granules
  • Cryptococcus neoformans
 

Citation

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Kozubowski, L., Aboobakar, E. F., Cardenas, M. E., & Heitman, J. (2011). Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryot Cell, 10(11), 1396–1402. https://doi.org/10.1128/EC.05087-11
Kozubowski, Lukasz, Eanas F. Aboobakar, Maria E. Cardenas, and Joseph Heitman. “Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.Eukaryot Cell 10, no. 11 (November 2011): 1396–1402. https://doi.org/10.1128/EC.05087-11.
Kozubowski L, Aboobakar EF, Cardenas ME, Heitman J. Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryot Cell. 2011 Nov;10(11):1396–402.
Kozubowski, Lukasz, et al. “Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.Eukaryot Cell, vol. 10, no. 11, Nov. 2011, pp. 1396–402. Pubmed, doi:10.1128/EC.05087-11.
Kozubowski L, Aboobakar EF, Cardenas ME, Heitman J. Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryot Cell. 2011 Nov;10(11):1396–1402.

Published In

Eukaryot Cell

DOI

EISSN

1535-9786

Publication Date

November 2011

Volume

10

Issue

11

Start / End Page

1396 / 1402

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Stress, Physiological
  • Poly(A)-Binding Proteins
  • Microbiology
  • Hot Temperature
  • Gene Expression Regulation, Fungal
  • Endoplasmic Reticulum
  • Endopeptidases
  • Cytoplasmic Granules
  • Cryptococcus neoformans