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The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.

Publication ,  Journal Article
Rohde, JR; Cardenas, ME
Published in: Mol Cell Biol
January 2003

The Tor pathway mediates cell growth in response to nutrient availability, in part by inducing ribosomal protein (RP) gene expression via an unknown mechanism. Expression of RP genes coincides with recruitment of the Esa1 histone acetylase to RP gene promoters. We show that inhibition of Tor with rapamycin releases Esa1 from RP gene promoters and leads to histone H4 deacetylation without affecting promoter occupancy by Rap1 and Abf1. Genetic and biochemical evidence identifies Rpd3 as the major histone deacetylase responsible for reversing histone H4 acetylation at RP gene promoters in response to Tor inhibition by rapamycin or nutrient limitation. Our results illustrate that the Tor pathway links nutrient sensing with histone acetylation to control RP gene expression and cell growth.

Duke Scholars

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

January 2003

Volume

23

Issue

2

Start / End Page

629 / 635

Location

United States

Related Subject Headings

  • Transcription Factors
  • Time Factors
  • Telomere-Binding Proteins
  • Sirolimus
  • Signal Transduction
  • Shelterin Complex
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Protein Binding
  • Promoter Regions, Genetic
 

Citation

APA
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ICMJE
MLA
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Rohde, J. R., & Cardenas, M. E. (2003). The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol Cell Biol, 23(2), 629–635. https://doi.org/10.1128/MCB.23.2.629-635.2003
Rohde, John R., and Maria E. Cardenas. “The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.Mol Cell Biol 23, no. 2 (January 2003): 629–35. https://doi.org/10.1128/MCB.23.2.629-635.2003.
Rohde JR, Cardenas ME. The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol Cell Biol. 2003 Jan;23(2):629–35.
Rohde, John R., and Maria E. Cardenas. “The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.Mol Cell Biol, vol. 23, no. 2, Jan. 2003, pp. 629–35. Pubmed, doi:10.1128/MCB.23.2.629-635.2003.
Rohde JR, Cardenas ME. The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol Cell Biol. 2003 Jan;23(2):629–635.

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

January 2003

Volume

23

Issue

2

Start / End Page

629 / 635

Location

United States

Related Subject Headings

  • Transcription Factors
  • Time Factors
  • Telomere-Binding Proteins
  • Sirolimus
  • Signal Transduction
  • Shelterin Complex
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Protein Binding
  • Promoter Regions, Genetic