Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.
Published
Journal Article (Review)
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten in the intestinal mucosa of patients with DH results in minimal clinical symptoms, allowing the continued ingestion of gluten and the eventual development of DH. Our model may provide a new way to understand the pathogenesis of other skin diseases associated with gastrointestinal inflammation such as pyoderma gangrenosum or erythema nodosum, or explain association of seronegative inflammatory arthritis with inflammatory bowel disease.
Full Text
Duke Authors
Cited Authors
- Cardones, ARG; Hall, RP
Published Date
- July 2011
Published In
Volume / Issue
- 29 / 3
Start / End Page
- 469 - x
PubMed ID
- 21605814
Pubmed Central ID
- 21605814
Electronic International Standard Serial Number (EISSN)
- 1558-0520
Digital Object Identifier (DOI)
- 10.1016/j.det.2011.03.005
Language
- eng
Conference Location
- United States