Building a new conceptual framework for receptor heteromers.


Journal Article

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

Full Text

Duke Authors

Cited Authors

  • Ferré, S; Baler, R; Bouvier, M; Caron, MG; Devi, LA; Durroux, T; Fuxe, K; George, SR; Javitch, JA; Lohse, MJ; Mackie, K; Milligan, G; Pfleger, KDG; Pin, J-P; Volkow, ND; Waldhoer, M; Woods, AS; Franco, R

Published Date

  • March 2009

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 131 - 134

PubMed ID

  • 19219011

Pubmed Central ID

  • 19219011

Electronic International Standard Serial Number (EISSN)

  • 1552-4469

Digital Object Identifier (DOI)

  • 10.1038/nchembio0309-131


  • eng

Conference Location

  • United States