Hedgehog signaling: is Smo a G protein-coupled receptor?

Journal Article (Journal Article;Review)

The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.

Full Text

Duke Authors

Cited Authors

  • Philipp, M; Caron, MG

Published Date

  • February 10, 2009

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • R125 - R127

PubMed ID

  • 19211052

Electronic International Standard Serial Number (EISSN)

  • 1879-0445

Digital Object Identifier (DOI)

  • 10.1016/j.cub.2008.12.010


  • eng

Conference Location

  • England