Akt/GSK3 signaling in the action of psychotropic drugs.

Published

Journal Article (Review)

Psychotropic drugs acting on monoamine neurotransmission are major pharmacological treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar disorder, Tourette syndrome, ADHD, and Alzheimer disease. Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT). These signaling molecules have also received attention for their role in the actions of psychoactive drugs such as antidepressants, antipsychotics, lithium, and other mood stabilizers. Furthermore, investigations of the mechanism by which D2 dopamine receptors regulate Akt/GSK3 signaling strongly support the physiological relevance of a new modality of G protein-coupled receptor (GPCR) signaling involving the multifunctional scaffolding protein beta-arrestin 2. Elucidation of the contribution of multiple signaling pathways to the action of psychotropic drugs may provide a better biological understanding of psychiatric disorders and lead to more efficient therapeutics.

Full Text

Duke Authors

Cited Authors

  • Beaulieu, J-M; Gainetdinov, RR; Caron, MG

Published Date

  • 2009

Published In

Volume / Issue

  • 49 /

Start / End Page

  • 327 - 347

PubMed ID

  • 18928402

Pubmed Central ID

  • 18928402

International Standard Serial Number (ISSN)

  • 0362-1642

Digital Object Identifier (DOI)

  • 10.1146/annurev.pharmtox.011008.145634

Language

  • eng

Conference Location

  • United States