Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice.

Journal Article (Journal Article)

Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity relative to wild-type mice. Atypical antipsychotics are effective treatments of schizophrenia and manic symptoms, presumably in part by antagonizing DA receptors. Here we report that treatment with clozapine (3 mg/kg) or quetiapine (2.5 mg/kg) attenuated prepulse inhibition deficits in male DAT knockout mice. Thus male DAT knockout mice may provide a useful animal model for predicting the efficacy of novel drugs in treating psychiatric illnesses characterized by a dysregulated DA system.

Full Text

Duke Authors

Cited Authors

  • Powell, SB; Young, JW; Ong, JC; Caron, MG; Geyer, MA

Published Date

  • September 2008

Published In

Volume / Issue

  • 19 / 5-6

Start / End Page

  • 562 - 565

PubMed ID

  • 18690110

Pubmed Central ID

  • PMC2693185

International Standard Serial Number (ISSN)

  • 0955-8810

Digital Object Identifier (DOI)

  • 10.1097/FBP.0b013e32830dc110


  • eng

Conference Location

  • England