Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter.

Published

Journal Article (Review)

The plasma membrane dopamine transporter (DAT) tightly regulates the extracellular concentrations of dopamine (DA) by re-capturing released neurotransmitter back into the presynaptic neuronal terminals and/or neighboring DA projections thereby providing an effective way to regulate synaptic and extrasynaptic DA levels. This transporter is a primary target of many potent psychotropic drugs and neurotoxins, such as cocaine, amphetamines and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this review we summarize recent advances in understanding the structure, regulation, and functional roles of DAT in normal DA physiology and pathological conditions, such as attention deficit hyperactivity disorder (ADHD) and neurodegenerative processes, as well as their contribution to the pharmacology of psychostimulant drugs. Significant new insights on these issues have been gained using mice with genetic deletion of DAT.

Full Text

Duke Authors

Cited Authors

  • Sotnikova, TD; Beaulieu, J-M; Gainetdinov, RR; Caron, MG

Published Date

  • February 2006

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 45 - 56

PubMed ID

  • 16613553

Pubmed Central ID

  • 16613553

Electronic International Standard Serial Number (EISSN)

  • 1996-3181

International Standard Serial Number (ISSN)

  • 1871-5273

Digital Object Identifier (DOI)

  • 10.2174/187152706784111579

Language

  • eng