Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2.

Journal Article (Journal Article;Review)

Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.

Full Text

Duke Authors

Cited Authors

  • Zhang, X; Beaulieu, J-M; Gainetdinov, RR; Caron, MG

Published Date

  • January 2006

Published In

Volume / Issue

  • 63 / 1

Start / End Page

  • 6 - 11

PubMed ID

  • 16378243

Pubmed Central ID

  • PMC2792355

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/s00018-005-5417-4


  • eng

Conference Location

  • Switzerland