Beta-arrestin goes nuclear.

Journal Article

Arrestins have important roles in the cytoplasm and at the plasma membrane, including the desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters.

Full Text

Duke Authors

Cited Authors

  • Beaulieu, J-M; Caron, MG

Published Date

  • December 2, 2005

Published In

Volume / Issue

  • 123 / 5

Start / End Page

  • 755 - 757

PubMed ID

  • 16325568

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2005.11.010

Language

  • eng

Conference Location

  • United States