Tryptophan hydroxylase-2 controls brain serotonin synthesis.


Journal Article

Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis.

Full Text

Duke Authors

Cited Authors

  • Zhang, X; Beaulieu, J-M; Sotnikova, TD; Gainetdinov, RR; Caron, MG

Published Date

  • July 9, 2004

Published In

Volume / Issue

  • 305 / 5681

Start / End Page

  • 217 -

PubMed ID

  • 15247473

Pubmed Central ID

  • 15247473

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1097540


  • eng

Conference Location

  • United States