Combined catecholamine and indoleamine depletion following response to ECT.
Publication
, Journal Article
Cassidy, F; Weiner, RD; Cooper, TB; Carroll, BJ
Published in: Br J Psychiatry
June 2010
The mechanism of action of electroconvulsive therapy (ECT) in treating major depression is unknown. We studied two candidate mechanisms through inhibiting simultaneously the synthesis of noradrenaline and serotonin in patients immediately after successful treatment with ECT using a randomised, placebo-controlled, double-blind crossover design. There were no significant changes in depression scores under any experimental conditions, or between the amine-depleted and placebo groups despite reductions of 61% in serum homovanillic acid, 47% in 3-methoxy-4-hydroxyenylethyleneglycol, and 89% in serum tryptophan. Catecholamine and serotonin availability may not be necessary for maintaining the initial antidepressant response to ECT.
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Published In
Br J Psychiatry
DOI
EISSN
1472-1465
Publication Date
June 2010
Volume
196
Issue
6
Start / End Page
493 / 494
Location
England
Related Subject Headings
- Tryptophan
- Treatment Outcome
- Serotonin
- Psychiatry
- Psychiatric Status Rating Scales
- Norepinephrine
- Middle Aged
- Male
- Humans
- Homovanillic Acid
Citation
APA
Chicago
ICMJE
MLA
NLM
Cassidy, F., Weiner, R. D., Cooper, T. B., & Carroll, B. J. (2010). Combined catecholamine and indoleamine depletion following response to ECT. Br J Psychiatry, 196(6), 493–494. https://doi.org/10.1192/bjp.bp.109.070573
Cassidy, Frederick, Richard D. Weiner, Thomas B. Cooper, and Bernard J. Carroll. “Combined catecholamine and indoleamine depletion following response to ECT.” Br J Psychiatry 196, no. 6 (June 2010): 493–94. https://doi.org/10.1192/bjp.bp.109.070573.
Cassidy F, Weiner RD, Cooper TB, Carroll BJ. Combined catecholamine and indoleamine depletion following response to ECT. Br J Psychiatry. 2010 Jun;196(6):493–4.
Cassidy, Frederick, et al. “Combined catecholamine and indoleamine depletion following response to ECT.” Br J Psychiatry, vol. 196, no. 6, June 2010, pp. 493–94. Pubmed, doi:10.1192/bjp.bp.109.070573.
Cassidy F, Weiner RD, Cooper TB, Carroll BJ. Combined catecholamine and indoleamine depletion following response to ECT. Br J Psychiatry. 2010 Jun;196(6):493–494.
Published In
Br J Psychiatry
DOI
EISSN
1472-1465
Publication Date
June 2010
Volume
196
Issue
6
Start / End Page
493 / 494
Location
England
Related Subject Headings
- Tryptophan
- Treatment Outcome
- Serotonin
- Psychiatry
- Psychiatric Status Rating Scales
- Norepinephrine
- Middle Aged
- Male
- Humans
- Homovanillic Acid