Design tools for digital microfluidic biochips: Toward functional diversification and more than Moore


Journal Article

Microfluidics-based biochips enable the precise control of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and they integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. Compared to conventional laboratory procedures, which are cumbersome and expensive, miniaturized biochips offer the advantages of higher sensitivity, lower cost due to smaller sample and reagent volumes, system integration, and less likelihood of human error. This paper first describes the droplet-based digital microfluidic technology platform and emerging applications. The physical principles underlying droplet actuation are next described. Finally, the paper presents computer-aided design tools for simulation, synthesis and chip optimization. These tools target modeling and simulation, scheduling, module placement, droplet routing, pin-constrained chip design, and testing. © 2006 IEEE.

Full Text

Duke Authors

Cited Authors

  • Chakrabarty, K; Fair, RB; Zeng, J

Published Date

  • July 1, 2010

Published In

Volume / Issue

  • 29 / 7

Start / End Page

  • 1001 - 1017

International Standard Serial Number (ISSN)

  • 0278-0070

Digital Object Identifier (DOI)

  • 10.1109/TCAD.2010.2049153

Citation Source

  • Scopus