The homeodomain protein HOXB13 regulates the cellular response to androgens.

Journal Article

HOXB13 is a member of the homeodomain family of sequence-specific transcription factors and, together with the androgen receptor (AR), plays a critical role in the normal development of the prostate gland. We demonstrate here that, in prostate cancer cells, HOXB13 is a key determinant of the response to androgens. Specifically, it was determined that HOXB13 interacts with the DNA-binding domain of AR and inhibits the transcription of genes that contain an androgen-response element (ARE). In contrast, the AR:HOXB13 complex confers androgen responsiveness to promoters that contain a specific HOXB13-response element. Further, HOXB13 and AR synergize to enhance the transcription of genes that contain a HOX element juxtaposed to an ARE. The profound effects of HOXB13 knockdown on androgen-regulated proliferation, migration, and lipogenesis in prostate cancer cells highlight the importance of the observed changes in gene expression.

Full Text

Duke Authors

Cited Authors

  • Norris, JD; Chang, C-Y; Wittmann, BM; Kunder, RS; Cui, H; Fan, D; Joseph, JD; McDonnell, DP

Published Date

  • November 13, 2009

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 405 - 416

PubMed ID

  • 19917249

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2009.10.020

Language

  • eng

Conference Location

  • United States