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The homeodomain protein HOXB13 regulates the cellular response to androgens.

Publication ,  Journal Article
Norris, JD; Chang, C-Y; Wittmann, BM; Kunder, RS; Cui, H; Fan, D; Joseph, JD; McDonnell, DP
Published in: Mol Cell
November 13, 2009

HOXB13 is a member of the homeodomain family of sequence-specific transcription factors and, together with the androgen receptor (AR), plays a critical role in the normal development of the prostate gland. We demonstrate here that, in prostate cancer cells, HOXB13 is a key determinant of the response to androgens. Specifically, it was determined that HOXB13 interacts with the DNA-binding domain of AR and inhibits the transcription of genes that contain an androgen-response element (ARE). In contrast, the AR:HOXB13 complex confers androgen responsiveness to promoters that contain a specific HOXB13-response element. Further, HOXB13 and AR synergize to enhance the transcription of genes that contain a HOX element juxtaposed to an ARE. The profound effects of HOXB13 knockdown on androgen-regulated proliferation, migration, and lipogenesis in prostate cancer cells highlight the importance of the observed changes in gene expression.

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Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

November 13, 2009

Volume

36

Issue

3

Start / End Page

405 / 416

Location

United States

Related Subject Headings

  • Transfection
  • Reverse Transcriptase Polymerase Chain Reaction
  • Response Elements
  • Recombinant Fusion Proteins
  • Receptors, Androgen
  • RNA, Small Interfering
  • Protein Binding
  • Prostatic Neoplasms
  • Metribolone
  • Male
 

Citation

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Norris, J. D., Chang, C.-Y., Wittmann, B. M., Kunder, R. S., Cui, H., Fan, D., … McDonnell, D. P. (2009). The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol Cell, 36(3), 405–416. https://doi.org/10.1016/j.molcel.2009.10.020
Norris, John D., Ching-Yi Chang, Bryan M. Wittmann, Rebecca S. Kunder, Huaxia Cui, Daju Fan, James D. Joseph, and Donald P. McDonnell. “The homeodomain protein HOXB13 regulates the cellular response to androgens.Mol Cell 36, no. 3 (November 13, 2009): 405–16. https://doi.org/10.1016/j.molcel.2009.10.020.
Norris JD, Chang C-Y, Wittmann BM, Kunder RS, Cui H, Fan D, et al. The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol Cell. 2009 Nov 13;36(3):405–16.
Norris, John D., et al. “The homeodomain protein HOXB13 regulates the cellular response to androgens.Mol Cell, vol. 36, no. 3, Nov. 2009, pp. 405–16. Pubmed, doi:10.1016/j.molcel.2009.10.020.
Norris JD, Chang C-Y, Wittmann BM, Kunder RS, Cui H, Fan D, Joseph JD, McDonnell DP. The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol Cell. 2009 Nov 13;36(3):405–416.
Journal cover image

Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

November 13, 2009

Volume

36

Issue

3

Start / End Page

405 / 416

Location

United States

Related Subject Headings

  • Transfection
  • Reverse Transcriptase Polymerase Chain Reaction
  • Response Elements
  • Recombinant Fusion Proteins
  • Receptors, Androgen
  • RNA, Small Interfering
  • Protein Binding
  • Prostatic Neoplasms
  • Metribolone
  • Male