Androgen receptor-cofactor interactions as targets for new drug discovery.

Journal Article (Journal Article;Review)

Cofactor recruitment is a crucial regulatory step in nuclear receptor signal transduction. Given the obligate nature of interactions between cofactors and these receptors for transcriptional activity, it is likely that drugs that target coactivator interaction surfaces will function as pure antagonists with particular utility in the treatment of estrogen- and androgen-dependent cancers. Recent crystallographic analysis of one of the major protein-protein interaction surfaces on the androgen receptor has raised expectations that it will be possible to develop small-molecule antagonists that block cofactor interactions.

Full Text

Duke Authors

Cited Authors

  • Chang, C-Y; McDonnell, DP

Published Date

  • May 2005

Published In

Volume / Issue

  • 26 / 5

Start / End Page

  • 225 - 228

PubMed ID

  • 15860367

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England