Role of the aryl hydrocarbon receptor in cell cycle regulation.

Published

Journal Article (Review)

One of the most puzzling aspects of the biological impact of polycyclic aromatic hydrocarbon compounds is that they elicit an apparently unrelated variety of toxic, teratogenic, and carcinogenic responses in exposed animals and in humans. At the cellular level, these environmental toxicants affect cell cycle regulatory mechanisms and signal transduction pathways in ways that are equally diverse and often contradictory. For example, depending on the particular cell lines studied, exposure to these compounds may lead to cell proliferation, to terminal differentiation, or to apoptosis. These effects are mediated by the aryl hydrocarbon receptor, a ligand-activated transcription factor well known for its regulatory activity on the expression of several phase I detoxification cytochrome P450 genes. Research into the molecular mechanisms of aryl hydrocarbon receptor function has uncovered a novel role for this protein during cell cycle progression. The activated receptor acts as an environmental sensor and cell cycle checkpoint that commits cells exposed to adverse environmental stimuli to arrest before the onset of DNA replication.

Full Text

Duke Authors

Cited Authors

  • Puga, A; Marlowe, J; Barnes, S; Chang, C-Y; Maier, A; Tan, Z; Kerzee, JK; Chang, X; Strobeck, M; Knudsen, ES

Published Date

  • December 27, 2002

Published In

Volume / Issue

  • 181-182 /

Start / End Page

  • 171 - 177

PubMed ID

  • 12505305

Pubmed Central ID

  • 12505305

International Standard Serial Number (ISSN)

  • 0300-483X

Digital Object Identifier (DOI)

  • 10.1016/s0300-483x(02)00276-7

Language

  • eng

Conference Location

  • Ireland