Control of GVHD: It's in our DNA!


Journal Article

Selective depletion of the alloreactiveT cells causing graft-versus-host disease (GVHD) without loss of the graft-versus-leukemia (GVL) effect is the holy grail of hematopoietic cell transplantation (HCT). In this issue of Blood, He et al demonstrate that inhibition of histone methylation leads to selective apoptosis of the alloreactive effector cells. 1 Moreover, they demonstrate that this inhibition of histone methylation remarkably stops ongoing GVHD.

Full Text

Duke Authors

Cited Authors

  • Chao, N

Published Date

  • February 2, 2012

Published In

Volume / Issue

  • 119 / 5

Start / End Page

  • 1102 - 1103

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2011-12-395905

Citation Source

  • Scopus