Minors come of age: Minor histocompatibility antigens and graft-versus-host disease.


Journal Article (Review)

Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation. These miHA are peptide fragments that are associated with major histocompatibility complex class I or class II antigens. Elegant experiments have led to the molecular characterization of these antigens. Efforts to prevent graft-versus-host disease could be targeted through this pathway by matching for these miHA or by preventing antigen recognition. Alternatively, these miHA could be exploited as targets for a more potent graft-versus-malignancy effect. This area of miHA promises to continue to be an exciting area of continued research.

Full Text

Duke Authors

Cited Authors

  • Chao, NJ

Published Date

  • April 2004

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 215 - 223

PubMed ID

  • 15077220

Pubmed Central ID

  • 15077220

International Standard Serial Number (ISSN)

  • 1083-8791

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2003.10.003


  • eng

Conference Location

  • United States