Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens.

Journal Article (Journal Article;Review)

Unrelated umbilical cord blood (UCB) transplantation has recently been explored in an increasing number of adult patients. The relative ease of procurement and the lower-than-anticipated risk of severe acute graft-versus-host disease has made UCB transplantation an appealing alternative to bone marrow-derived hematopoietic stem cells. The use of reduced-intensity or nonmyeloablative preparative regimens to allow engraftment of UCB broadens the scope of patients who may benefit from allogeneic immunotherapy, including elderly and medically infirm patients with no matched sibling donor. This review summarizes the available data on the use of UCB as an alternative source of hematopoietic stem cell transplantation in adult patients.

Full Text

Duke Authors

Cited Authors

  • Koh, L-P; Chao, NJ

Published Date

  • January 2004

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 1 - 22

PubMed ID

  • 14752775

International Standard Serial Number (ISSN)

  • 1083-8791

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2003.09.009


  • eng

Conference Location

  • United States