Depletion of host reactive T cells by photodynamic cell purging and prevention of graft versus host disease.

Journal Article (Journal Article;Review)

Graft versus Host Disease (GVHD) is the principal cause of morbidity and mortality in patients undergoing allogeneic stem cell transplant. T cell depletion has been recognized as a method of reducing the incidence of GVHD in allogeneic transplants. Until recently, most T cell depletion methods were non-selective in reducing lymphocytes. Rhodamine purging is one method, which selectively reduces alloreactive T cells preventing GVHD. We review here the methods of non-selective and selective T cell depletion, particularly the newer method of photodynamic purging utilizing rhodamine.

Full Text

Duke Authors

Cited Authors

  • Goggins, TF; Chao, N

Published Date

  • November 2003

Published In

Volume / Issue

  • 44 / 11

Start / End Page

  • 1871 - 1879

PubMed ID

  • 14738138

International Standard Serial Number (ISSN)

  • 1042-8194

Digital Object Identifier (DOI)

  • 10.1080/1042819031000119226

Language

  • eng

Conference Location

  • United States