Depletion of host reactive T cells by photodynamic cell purging and prevention of graft versus host disease.


Journal Article (Review)

Graft versus Host Disease (GVHD) is the principal cause of morbidity and mortality in patients undergoing allogeneic stem cell transplant. T cell depletion has been recognized as a method of reducing the incidence of GVHD in allogeneic transplants. Until recently, most T cell depletion methods were non-selective in reducing lymphocytes. Rhodamine purging is one method, which selectively reduces alloreactive T cells preventing GVHD. We review here the methods of non-selective and selective T cell depletion, particularly the newer method of photodynamic purging utilizing rhodamine.

Full Text

Duke Authors

Cited Authors

  • Goggins, TF; Chao, N

Published Date

  • November 2003

Published In

Volume / Issue

  • 44 / 11

Start / End Page

  • 1871 - 1879

PubMed ID

  • 14738138

Pubmed Central ID

  • 14738138

International Standard Serial Number (ISSN)

  • 1042-8194

Digital Object Identifier (DOI)

  • 10.1080/1042819031000119226


  • eng

Conference Location

  • United States