Depletion of host reactive T cells by photodynamic cell purging and prevention of graft versus host disease.
Journal Article (Journal Article;Review)
Graft versus Host Disease (GVHD) is the principal cause of morbidity and mortality in patients undergoing allogeneic stem cell transplant. T cell depletion has been recognized as a method of reducing the incidence of GVHD in allogeneic transplants. Until recently, most T cell depletion methods were non-selective in reducing lymphocytes. Rhodamine purging is one method, which selectively reduces alloreactive T cells preventing GVHD. We review here the methods of non-selective and selective T cell depletion, particularly the newer method of photodynamic purging utilizing rhodamine.
- Goggins, TF; Chao, N
- November 2003
Volume / Issue
- 44 / 11
Start / End Page
- 1871 - 1879
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States