Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article (Journal Article)

A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance thermal imaging (MRTI) is used to measure 2D temperature rise distributions in four cross sections of large extremity soft tissue sarcomas during hyperthermia treatments. Novel hardware and software techniques are described which improve the signal to noise ratio of MR images, minimize motion artifact from circulating coupling fluids, and provide accurate high resolution volumetric thermal dosimetry. For the first 10 extremity sarcoma patients, the mean difference between MRTI region of interest and adjacent interstitial point measurements during the period of steady state temperature was 0.85°C. With 1min temporal resolution of measurements in four image planes, this non-invasive MRTI approach has demonstrated its utility for accurate monitoring and realtime steering of heat into tumors at depth in the body.

Full Text

Duke Authors

Cited Authors

  • Stauffer, P; Craciunescu, O; Maccarini, P; Wyatt, C; Arunachalam, K; Arabe, O; Stakhursky, V; Li, Z; Soher, B; Macfall, J; Rangarao, S; Cheng, K; Das, S; Martins, C; Charles, C; Dewhirst, M; Wong, T; Jones, E; Vujaskovic, Z

Published Date

  • February 25, 2009

Published In

Volume / Issue

  • 7181 /

PubMed ID

  • 24224074

Pubmed Central ID

  • PMC3820377

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.812188


  • eng

Conference Location

  • United States