African strains of hepatitis E virus that are distinct from Asian strains.

Journal Article (Journal Article)

Partial genomic sequences of four hepatitis E virus (HEV) strains from Africa (Morocco and Tunisia) and one from Central Asia (Tashkent, Uzbekistan) were obtained. The reverse transcriptase-polymerase chain reaction was used to amplify 5' and hypervariable regions of open reading frame 1 (ORF1) and a region overlapping all 3 ORFs. Sequence analysis of these regions revealed the African strains to be quite distinct from all known Asian strains but more similar to them than to the Mexican strain. Sequence analysis of the Tashkent strain revealed almost complete identity with another central Asian strain from Osh, Kirgizia. These results thus further confirm the geographical origin of HEV strain divergence.

Full Text

Duke Authors

Cited Authors

  • Chatterjee, R; Tsarev, S; Pillot, J; Coursaget, P; Emerson, SU; Purcell, RH

Published Date

  • October 1997

Published In

Volume / Issue

  • 53 / 2

Start / End Page

  • 139 - 144

PubMed ID

  • 9334924

International Standard Serial Number (ISSN)

  • 0146-6615


  • eng

Conference Location

  • United States