The role of dynamin in HIV type 1 Env-mediated cell-cell fusion.

Published

Journal Article

HIV-1 envelope glycoproteins are the key viral proteins that mediate HIV-1 entry and cell-cell fusion. In contrast to HIV-1 entry, the mechanism of HIV-1 Env-mediated cell-cell fusion is relatively unclear. This study demonstrated that dynasore, a dynamin inhibitor, suppressed HIV-1 Env-mediated cell-cell fusion. Dynasore sensitivity of HIV-1 Env-mediated cell-cell fusion varied depending on the viral strains. Results from testing a panel of gp41 cytoplasmic tail truncation mutants suggested that the gp41 cytoplasmic tail might play a role in dynasore sensitivity. HIV-1 Env-mediated cell-cell fusion could also be suppressed by a dynamin dominant-negative mutant DNM2(K44A). In summary, these results suggested that dynamin 2 might play a role in HIV-1 Env-mediated cell-cell fusion.

Full Text

Duke Authors

Cited Authors

  • Lai, W; Huang, L; Ho, P; Montefiori, D; Chen, C-H

Published Date

  • September 2011

Published In

Volume / Issue

  • 27 / 9

Start / End Page

  • 1013 - 1017

PubMed ID

  • 21338326

Pubmed Central ID

  • 21338326

Electronic International Standard Serial Number (EISSN)

  • 1931-8405

International Standard Serial Number (ISSN)

  • 0889-2229

Digital Object Identifier (DOI)

  • 10.1089/aid.2010.0259

Language

  • eng