Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.
Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4-6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC(90) 0.40 nM) with the lowest cytotoxicity (IC(50) 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.
Asada, Y; Sukemori, A; Watanabe, T; Malla, KJ; Yoshikawa, T; Li, W; Koike, K; Chen, C-H; Akiyama, T; Qian, K; Nakagawa-Goto, K; Morris-Natschke, SL; Lee, K-H
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