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Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

Publication ,  Journal Article
Asada, Y; Sukemori, A; Watanabe, T; Malla, KJ; Yoshikawa, T; Li, W; Koike, K; Chen, C-H; Akiyama, T; Qian, K; Nakagawa-Goto, K; Lee, K-H ...
Published in: Org Lett
June 3, 2011

Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4-6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC(90) 0.40 nM) with the lowest cytotoxicity (IC(50) 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.

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Published In

Org Lett

DOI

EISSN

1523-7052

Publication Date

June 3, 2011

Volume

13

Issue

11

Start / End Page

2904 / 2907

Location

United States

Related Subject Headings

  • Thymelaeaceae
  • Organic Chemistry
  • Molecular Structure
  • Diterpenes
  • Anti-HIV Agents
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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Asada, Y., Sukemori, A., Watanabe, T., Malla, K. J., Yoshikawa, T., Li, W., … Lee, K.-H. (2011). Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. Org Lett, 13(11), 2904–2907. https://doi.org/10.1021/ol200889s
Asada, Yoshihisa, Aya Sukemori, Takashi Watanabe, Kuber J. Malla, Takafumi Yoshikawa, Wei Li, Kazuo Koike, et al. “Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.Org Lett 13, no. 11 (June 3, 2011): 2904–7. https://doi.org/10.1021/ol200889s.
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, et al. Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. Org Lett. 2011 Jun 3;13(11):2904–7.
Asada, Yoshihisa, et al. “Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.Org Lett, vol. 13, no. 11, June 2011, pp. 2904–07. Pubmed, doi:10.1021/ol200889s.
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Koike K, Chen C-H, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lee K-H. Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. Org Lett. 2011 Jun 3;13(11):2904–2907.
Journal cover image

Published In

Org Lett

DOI

EISSN

1523-7052

Publication Date

June 3, 2011

Volume

13

Issue

11

Start / End Page

2904 / 2907

Location

United States

Related Subject Headings

  • Thymelaeaceae
  • Organic Chemistry
  • Molecular Structure
  • Diterpenes
  • Anti-HIV Agents
  • 34 Chemical sciences
  • 03 Chemical Sciences