HIV entry inhibitors: progress in development and application.
Journal Article (Journal Article;Review)
This review discusses recent progress in the development of anti-HIV agents, with emphasis on small molecule HIV-1 entry inhibitors. The entry inhibitors primarily target HIV-1 envelope glycoproteins or the cellular receptors, CD4 and chemokine receptors. Two of the entry inhibitors, enfuvirtide and maraviroc, have been approved by the US FDA for AIDS therapy. The drug resistance associated with some of the entry inhibitors will also be discussed.
Full Text
Duke Authors
Cited Authors
- Lai, W-H; Huang, L; Chen, C-H
Published Date
- February 2010
Published In
Volume / Issue
- 45 / 2
Start / End Page
- 131 - 140
PubMed ID
- 21348414
International Standard Serial Number (ISSN)
- 0513-4870
Language
- eng
Conference Location
- China