Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

Journal Article

We previously reported that [[N-[3beta-hydroxyllup-20(29)-en-28-oyl]-7-aminoheptyl]carbamoyl]methane (A43D, 4) was a potent HIV-1 entry inhibitor. However, 4 was inactive against HIV-2 virus, suggesting the structural requirements for targeting these two retroviruses are different. In this study, a series of new betulinic acid derivatives were synthesized, and some of them displayed selective anti-HIV-2 activity at nanomolar concentrations. In comparison to compounds with anti-HIV-1 activity, a shorter C-28 side chain is required for optimal anti-HIV-2 activity.

Full Text

Duke Authors

Cited Authors

  • Dang, Z; Lai, W; Qian, K; Ho, P; Lee, K-H; Chen, C-H; Huang, L

Published Date

  • December 10, 2009

Published In

Volume / Issue

  • 52 / 23

Start / End Page

  • 7887 - 7891

PubMed ID

  • 19526990

Electronic International Standard Serial Number (EISSN)

  • 1520-4804

Digital Object Identifier (DOI)

  • 10.1021/jm9004253

Language

  • eng

Conference Location

  • United States