Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
Journal Article (Journal Article)
We previously reported that [[N-[3beta-hydroxyllup-20(29)-en-28-oyl]-7-aminoheptyl]carbamoyl]methane (A43D, 4) was a potent HIV-1 entry inhibitor. However, 4 was inactive against HIV-2 virus, suggesting the structural requirements for targeting these two retroviruses are different. In this study, a series of new betulinic acid derivatives were synthesized, and some of them displayed selective anti-HIV-2 activity at nanomolar concentrations. In comparison to compounds with anti-HIV-1 activity, a shorter C-28 side chain is required for optimal anti-HIV-2 activity.
Full Text
Duke Authors
Cited Authors
- Dang, Z; Lai, W; Qian, K; Ho, P; Lee, K-H; Chen, C-H; Huang, L
Published Date
- December 10, 2009
Published In
Volume / Issue
- 52 / 23
Start / End Page
- 7887 - 7891
PubMed ID
- 19526990
Pubmed Central ID
- PMC2788670
Electronic International Standard Serial Number (EISSN)
- 1520-4804
Digital Object Identifier (DOI)
- 10.1021/jm9004253
Language
- eng
Conference Location
- United States