Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.

Journal Article (Journal Article)

Human immunodeficiency virus (HIV) transmission through saliva is extremely low. Several oral components, including secretory immunoglobulin A and secretory leukocyte protease inhibitor, are known as potential inhibitory agents of HIV oral transmission. Here we examined anti-HIV activity of oral bacterial components. We showed that recombinant protein HGP44 derived from Porphyromonas gingivalis, one of the primary infectious agents of periodontitis, was capable of inhibiting HIV type 1 (HIV-1) replication. HGP44 bound specifically to HIV-1 gp120 and blocked HIV-1 envelope-mediated membrane fusion. These findings suggest that HGP44 of P. gingivalis can inhibit HIV-1 infection by blocking HIV-1 entry.

Full Text

Duke Authors

Cited Authors

  • Xie, H; Belogortseva, NI; Wu, J; Lai, W-H; Chen, C-H

Published Date

  • September 2006

Published In

Volume / Issue

  • 50 / 9

Start / End Page

  • 3070 - 3074

PubMed ID

  • 16940103

Pubmed Central ID

  • PMC1563519

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.01578-05


  • eng

Conference Location

  • United States