Betulinic acid derivatives as HIV-1 antivirals.

Journal Article (Journal Article;Review)

Betulinic acid (BA) derivatives are low molecular weight organic compounds synthesized from a plant-derived natural product. Several BA derivatives are potent and highly selective inhibitors of HIV-1. Depending on the specific side-chain modification, these compounds function by inhibiting HIV fusion or, as recently demonstrated, by interfering with a specific step in HIV-1 maturation. BA derivatives have potential as novel HIV-1 therapies, and additional studies of their mechanisms of action are likely to further define the novel targets of these compounds and elucidate the basic biology of HIV-1 fusion and maturation. In this review, recent studies of the novel mechanisms of action of this interesting class of antiviral compounds are discussed.

Full Text

Duke Authors

Cited Authors

  • Aiken, C; Chen, CH

Published Date

  • January 2005

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 31 - 36

PubMed ID

  • 15649820

International Standard Serial Number (ISSN)

  • 1471-4914

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2004.11.001


  • eng

Conference Location

  • England