Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.
Publication
, Journal Article
Huang, L; Yuan, X; Aiken, C; Chen, CH
Published in: Antimicrob Agents Chemother
February 2004
A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.
Duke Scholars
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Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
February 2004
Volume
48
Issue
2
Start / End Page
663 / 665
Location
United States
Related Subject Headings
- Virus Replication
- Triterpenes
- Structure-Activity Relationship
- Pentacyclic Triterpenes
- Microbiology
- HIV-1
- HIV Envelope Protein gp120
- HIV Core Protein p24
- Chlorocebus aethiops
- COS Cells
Citation
APA
Chicago
ICMJE
MLA
NLM
Huang, L., Yuan, X., Aiken, C., & Chen, C. H. (2004). Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrob Agents Chemother, 48(2), 663–665. https://doi.org/10.1128/AAC.48.2.663-665.2004
Huang, Li, Xiong Yuan, Christopher Aiken, and Chin Ho Chen. “Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.” Antimicrob Agents Chemother 48, no. 2 (February 2004): 663–65. https://doi.org/10.1128/AAC.48.2.663-665.2004.
Huang L, Yuan X, Aiken C, Chen CH. Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrob Agents Chemother. 2004 Feb;48(2):663–5.
Huang, Li, et al. “Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.” Antimicrob Agents Chemother, vol. 48, no. 2, Feb. 2004, pp. 663–65. Pubmed, doi:10.1128/AAC.48.2.663-665.2004.
Huang L, Yuan X, Aiken C, Chen CH. Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrob Agents Chemother. 2004 Feb;48(2):663–665.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
February 2004
Volume
48
Issue
2
Start / End Page
663 / 665
Location
United States
Related Subject Headings
- Virus Replication
- Triterpenes
- Structure-Activity Relationship
- Pentacyclic Triterpenes
- Microbiology
- HIV-1
- HIV Envelope Protein gp120
- HIV Core Protein p24
- Chlorocebus aethiops
- COS Cells