Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.
Journal Article (Journal Article)
A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.
Full Text
Duke Authors
Cited Authors
- Huang, L; Yuan, X; Aiken, C; Chen, CH
Published Date
- February 2004
Published In
Volume / Issue
- 48 / 2
Start / End Page
- 663 - 665
PubMed ID
- 14742233
Pubmed Central ID
- PMC321552
International Standard Serial Number (ISSN)
- 0066-4804
Digital Object Identifier (DOI)
- 10.1128/AAC.48.2.663-665.2004
Language
- eng
Conference Location
- United States