Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Journal Article (Journal Article)

A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.

Full Text

Duke Authors

Cited Authors

  • Huang, L; Yuan, X; Aiken, C; Chen, CH

Published Date

  • February 2004

Published In

Volume / Issue

  • 48 / 2

Start / End Page

  • 663 - 665

PubMed ID

  • 14742233

Pubmed Central ID

  • PMC321552

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.48.2.663-665.2004


  • eng

Conference Location

  • United States