Molecular targets of anti-HIV-1 triterpenes.

Journal Article (Journal Article;Review)

Pentacyclic triterpenes have been found in many plants and may be isolated from any part of the plant. Triterpene derivatives were shown to have biological activities including anti-HIV-1 and anti-cancer activities. The modes of action of the anti-HIV-1 triterpenes have been reported to be associated with the virus entry, reverse transcription, virus assembly and maturation. This review will focus on the mechanisms of action of anti-HIV triterpenes and the structural features that contribute to their anti-HIV-1 activity and site of action.

Full Text

Duke Authors

Cited Authors

  • Huang, L; Chen, CH

Published Date

  • March 2002

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 33 - 36

PubMed ID

  • 12462151

International Standard Serial Number (ISSN)

  • 1568-0053

Digital Object Identifier (DOI)

  • 10.2174/1568005024605936

Language

  • eng

Conference Location

  • Netherlands