Molecular targets of anti-HIV-1 triterpenes.


Journal Article (Review)

Pentacyclic triterpenes have been found in many plants and may be isolated from any part of the plant. Triterpene derivatives were shown to have biological activities including anti-HIV-1 and anti-cancer activities. The modes of action of the anti-HIV-1 triterpenes have been reported to be associated with the virus entry, reverse transcription, virus assembly and maturation. This review will focus on the mechanisms of action of anti-HIV triterpenes and the structural features that contribute to their anti-HIV-1 activity and site of action.

Full Text

Duke Authors

Cited Authors

  • Huang, L; Chen, CH

Published Date

  • March 2002

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 33 - 36

PubMed ID

  • 12462151

Pubmed Central ID

  • 12462151

International Standard Serial Number (ISSN)

  • 1568-0053

Digital Object Identifier (DOI)

  • 10.2174/1568005024605936


  • eng

Conference Location

  • Netherlands