Molecular targets of anti-HIV-1 triterpenes

Journal Article

Pentacyclic triterpenes have been found in many plants and may be isolated from any part of the plant. Triterpene derivatives were shown to have biological activities including anti-HIV-1 and anti-cancer activities. The modes of action of the anti-HIV-1 triterpenes have been reported to be associated with the virus entry, reverse transcription, virus assembly and maturation. This review will focus on the mechanisms of action of anti-HIV triterpenes and the structural features that contribute to their anti-HIV-1 activity and site of action.

Duke Authors

Cited Authors

  • Huang, L; Chen, CH

Published Date

  • 2002

Published In

  • Current Drug Targets - Infectious Disorders

Volume / Issue

  • 2 / 1

Start / End Page

  • 33 - 36

PubMed ID

  • 12462151