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23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing.

Publication ,  Journal Article
Hillenbrand, HB; Becker, LC; Kharrazian, R; Hu, K; Rochitte, CE; Kim, RJ; Chen, EL; Ertl, G; Hruban, RH; Lima, JAC
Published in: Magn Reson Med
April 2005

Although (23)Na MRI has been shown to delineate acute myocardial infarction (MI), the time course of in vivo (23)Na MRI during infarct healing remains unknown. In this study (23)Na MRI was combined with contrast-enhanced (CE) (1)H MRI to noninvasively characterize infarct healing in vivo. Serial in vivo 3D (23)Na MRI and (1)H MRI were performed for up to 9 weeks postinfarction in 10 dogs. Radioactive microspheres were used to measure myocardial perfusion, and Hematoxylin-Eosin (H&E) and Masson's trichrome (MT) staining were used to assess interstitial cell infiltrate and collagen content. In vivo (23)Na MRI accurately delineated infarct size up to day 5 postinfarction in comparison with (1)H MRI (8.9% +/- 8.1% vs. 8.6% +/- 7.9% on day 1 postinfarction, P = NS; and 6.3% +/- 6.2% vs. 6.2% +/- 6.2% on days 4/5 postinfarction, P = NS). The in vivo (23)Na MRI signal intensity, expressed as the signal intensity ratio of infarcted tissue vs. noninfarcted tissue (MI/R) peaked on day 1 of infarction (2.04 +/- 0.23) but decreased significantly to 1.27 at 9 weeks postinfarction (P < 0.05) due to granulation tissue infiltrate and collagen deposition. To confirm the MI/R decrease during scar formation ex vivo, we performed (23)Na MRI in 12 rats on day 3 post-MI (N = 5) and after 6 weeks (N = 7). H&E and Picrosirius Red staining confirmed granulation tissue infiltrate on day 3 and scar formation after 6 weeks. MI/R decreased significantly from 1.91 +/- 0.45 on day 3 post-MI to 1.3 +/- 0.09 after 6 weeks. Thus, in vivo (23)Na MRI accurately delineates infarct size up to day 5 postinfarction. In vivo (23)Na MRI signal intensity decreases during infarct healing as a result of the underlying infarct healing process.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

April 2005

Volume

53

Issue

4

Start / End Page

843 / 850

Location

United States

Related Subject Headings

  • Sodium Isotopes
  • Sodium
  • Regression Analysis
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hillenbrand, H. B., Becker, L. C., Kharrazian, R., Hu, K., Rochitte, C. E., Kim, R. J., … Lima, J. A. C. (2005). 23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing. Magn Reson Med, 53(4), 843–850. https://doi.org/10.1002/mrm.20417
Hillenbrand, Hanns B., Lewis C. Becker, Reza Kharrazian, Kai Hu, Carlos E. Rochitte, Raymond J. Kim, Enn L. Chen, Georg Ertl, Ralph H. Hruban, and João A. C. Lima. “23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing.Magn Reson Med 53, no. 4 (April 2005): 843–50. https://doi.org/10.1002/mrm.20417.
Hillenbrand HB, Becker LC, Kharrazian R, Hu K, Rochitte CE, Kim RJ, et al. 23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing. Magn Reson Med. 2005 Apr;53(4):843–50.
Hillenbrand, Hanns B., et al. “23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing.Magn Reson Med, vol. 53, no. 4, Apr. 2005, pp. 843–50. Pubmed, doi:10.1002/mrm.20417.
Hillenbrand HB, Becker LC, Kharrazian R, Hu K, Rochitte CE, Kim RJ, Chen EL, Ertl G, Hruban RH, Lima JAC. 23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing. Magn Reson Med. 2005 Apr;53(4):843–850.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

April 2005

Volume

53

Issue

4

Start / End Page

843 / 850

Location

United States

Related Subject Headings

  • Sodium Isotopes
  • Sodium
  • Regression Analysis
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted