A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA).
Publication
, Journal Article
Noyszewski, EA; Chen, EL; Reddy, R; Wang, Z; Leigh, JS
Published in: Magn Reson Med
November 1997
This paper describes a new, simplified pulse sequence for observing NMR signals from deoxymyoglobin in vivo. Paramagnetically shifted resonances from deoxymyoglobin can be exploited to noninvasively calculate intracellular oxygen tension in striated muscle. However, special sequences are required to observe these weak signals against the larger water and fat signals encountered in vivo. The pulse sequence described here, which is based on inversion recovery sequences, efficiently suppresses both water and fat resonances and can be implemented with short repetition rates. Moreover, it is perfectly suited for studies with surface coils, where RF inhomogeneities render other popular suppression sequences ineffective.
Duke Scholars
Published In
Magn Reson Med
DOI
ISSN
0740-3194
Publication Date
November 1997
Volume
38
Issue
5
Start / End Page
788 / 792
Location
United States
Related Subject Headings
- Nuclear Medicine & Medical Imaging
- Myoglobin
- Muscle, Skeletal
- Magnetic Resonance Spectroscopy
- Humans
- 0903 Biomedical Engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Noyszewski, E. A., Chen, E. L., Reddy, R., Wang, Z., & Leigh, J. S. (1997). A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA). Magn Reson Med, 38(5), 788–792. https://doi.org/10.1002/mrm.1910380515
Noyszewski, E. A., E. L. Chen, R. Reddy, Z. Wang, and J. S. Leigh. “A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA).” Magn Reson Med 38, no. 5 (November 1997): 788–92. https://doi.org/10.1002/mrm.1910380515.
Noyszewski EA, Chen EL, Reddy R, Wang Z, Leigh JS. A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA). Magn Reson Med. 1997 Nov;38(5):788–92.
Noyszewski, E. A., et al. “A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA).” Magn Reson Med, vol. 38, no. 5, Nov. 1997, pp. 788–92. Pubmed, doi:10.1002/mrm.1910380515.
Noyszewski EA, Chen EL, Reddy R, Wang Z, Leigh JS. A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA). Magn Reson Med. 1997 Nov;38(5):788–792.
Published In
Magn Reson Med
DOI
ISSN
0740-3194
Publication Date
November 1997
Volume
38
Issue
5
Start / End Page
788 / 792
Location
United States
Related Subject Headings
- Nuclear Medicine & Medical Imaging
- Myoglobin
- Muscle, Skeletal
- Magnetic Resonance Spectroscopy
- Humans
- 0903 Biomedical Engineering