A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA).

Journal Article (Journal Article)

This paper describes a new, simplified pulse sequence for observing NMR signals from deoxymyoglobin in vivo. Paramagnetically shifted resonances from deoxymyoglobin can be exploited to noninvasively calculate intracellular oxygen tension in striated muscle. However, special sequences are required to observe these weak signals against the larger water and fat signals encountered in vivo. The pulse sequence described here, which is based on inversion recovery sequences, efficiently suppresses both water and fat resonances and can be implemented with short repetition rates. Moreover, it is perfectly suited for studies with surface coils, where RF inhomogeneities render other popular suppression sequences ineffective.

Full Text

Duke Authors

Cited Authors

  • Noyszewski, EA; Chen, EL; Reddy, R; Wang, Z; Leigh, JS

Published Date

  • November 1997

Published In

Volume / Issue

  • 38 / 5

Start / End Page

  • 788 - 792

PubMed ID

  • 9358453

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910380515


  • eng

Conference Location

  • United States