memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice
A major challenge in allogeneic hematopoietic cell transplantation is how to transfer T-cell immunity without causing graftversus- host disease (GVHD). Effector memory T cells (CD62L -) are a cell subset that can potentially address this challenge because they do not induce GVHD. Here, we investigated how CD62L - T cells contributed to phenotypic and functional T-cell reconstitution after transplantation. On transfer into allogeneic recipients, CD62L - T cells were activated and expressed multiple cytokines and cytotoxic molecules. CD62L - T cells were able to deplete host radioresistant T cells and facilitate hematopoietic engraftment, resulting in enhanced de novo T-cell regeneration. Enhanced functional immune reconstitution was demonstrated in CD62L -T-cell recipients using a tumor and an influenza virus challenge model. Even though CD62L - T cells are able to respond to alloantigens and deplete host radioresistant immune cells in GVHD recipients, alloreactive CD62L - T cells lost the reactivity over time and were eventually tolerant to alloantigens as a result of prolonged antigen exposure, suggesting a mechanism by which CD62L - T cells were able to eliminate host resistance without causing GVHD. These data further highlight the unique characteristics of CD62L - T cells and their potential applications in clinical hematopoietic cell transplantation. © 2012 by The American Society of Hematology.
Zhang, J; Barefoot, BE; Mo, W; Deoliveira, D; Son, J; Cui, X; Ramsburg, E; Chen, BJ
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)