High-resolution in vivo imaging of blood vessels without labeling.
Journal Article (Journal Article)
We demonstrate that both oxyhemoglobin and deoxyhemoglobin have sequential two-color, two-photon absorption properties that can serve as endogenous contrasts in microvasculature imaging. Using a sensitive modulation transfer technique, we are able to image hemoglobin in red blood cells with micrometer resolution, both in vitro and in vivo. We show that excellent contrast from hemoglobin without any labeling can be obtained in tissue.
Full Text
Duke Authors
Cited Authors
- Fu, D; Ye, T; Matthews, TE; Chen, BJ; Yurtserver, G; Warren, WS
Published Date
- September 15, 2007
Published In
Volume / Issue
- 32 / 18
Start / End Page
- 2641 - 2643
PubMed ID
- 17873920
International Standard Serial Number (ISSN)
- 0146-9592
Digital Object Identifier (DOI)
- 10.1364/ol.32.002641
Language
- eng
Conference Location
- United States