High-resolution in vivo imaging of blood vessels without labeling.

Published

Journal Article

We demonstrate that both oxyhemoglobin and deoxyhemoglobin have sequential two-color, two-photon absorption properties that can serve as endogenous contrasts in microvasculature imaging. Using a sensitive modulation transfer technique, we are able to image hemoglobin in red blood cells with micrometer resolution, both in vitro and in vivo. We show that excellent contrast from hemoglobin without any labeling can be obtained in tissue.

Full Text

Published version (via Digital Object Identifier)
Pubmed Central version

Duke Authors

Chen, Jun
Warren, Warren S.

Cited Authors

Fu, D; Ye, T; Matthews, TE; Chen, BJ; Yurtserver, G; Warren, WS

Published Date

September 2007

Published In

Optics Letters

Volume / Issue

32 / 18

Start / End Page

2641 - 2643

PubMed ID

17873920

Pubmed Central ID

17873920

Electronic International Standard Serial Number (EISSN)

1539-4794

International Standard Serial Number (ISSN)

0146-9592

Digital Object Identifier (DOI)

10.1364/ol.32.002641

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