Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
Lee, Y-C; Kuo, H-C; Chang, J-S; Chang, L-Y; Huang, L-M; Chen, M-R; Liang, C-D; Chi, H; Huang, F-Y; Lee, M-L; Huang, Y-C; Hwang, B; Chiu, N-C; Hwang, K-P; Lee, P-C; Chang, L-C; Liu, Y-M; Chen, Y-J; Chen, C-H; Taiwan Pediatric ID Alliance, ; Chen, Y-T; Tsai, F-J; Wu, J-Y
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