Skip to main content

Genome-wide association study of bipolar I disorder in the Han Chinese population.

Publication ,  Journal Article
Lee, MTM; Chen, CH; Lee, CS; Chen, CC; Chong, MY; Ouyang, WC; Chiu, NY; Chuo, LJ; Chen, CY; Tan, HKL; Lane, HY; Chang, TJ; Lin, CH; Jou, SH ...
Published in: Mol Psychiatry
May 2011

We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

May 2011

Volume

16

Issue

5

Start / End Page

548 / 556

Location

England

Related Subject Headings

  • Transcription Factors
  • Sialyltransferases
  • Reproducibility of Results
  • Psychiatry
  • Proteins
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Odds Ratio
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, M. T. M., Chen, C. H., Lee, C. S., Chen, C. C., Chong, M. Y., Ouyang, W. C., … Cheng, A. T. A. (2011). Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry, 16(5), 548–556. https://doi.org/10.1038/mp.2010.43
Lee, M. T. M., C. H. Chen, C. S. Lee, C. C. Chen, M. Y. Chong, W. C. Ouyang, N. Y. Chiu, et al. “Genome-wide association study of bipolar I disorder in the Han Chinese population.Mol Psychiatry 16, no. 5 (May 2011): 548–56. https://doi.org/10.1038/mp.2010.43.
Lee MTM, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry. 2011 May;16(5):548–56.
Lee, M. T. M., et al. “Genome-wide association study of bipolar I disorder in the Han Chinese population.Mol Psychiatry, vol. 16, no. 5, May 2011, pp. 548–56. Pubmed, doi:10.1038/mp.2010.43.
Lee MTM, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HKL, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Wang KHT, Fann CSJ, Wu JY, Chen YT, Cheng ATA. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry. 2011 May;16(5):548–556.

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

May 2011

Volume

16

Issue

5

Start / End Page

548 / 556

Location

England

Related Subject Headings

  • Transcription Factors
  • Sialyltransferases
  • Reproducibility of Results
  • Psychiatry
  • Proteins
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Odds Ratio
  • Male
  • Humans