Genome-wide association study of bipolar I disorder in the Han Chinese population.
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.
Lee, MTM; Chen, CH; Lee, CS; Chen, CC; Chong, MY; Ouyang, WC; Chiu, NY; Chuo, LJ; Chen, CY; Tan, HKL; Lane, HY; Chang, TJ; Lin, CH; Jou, SH; Hou, YM; Feng, J; Lai, TJ; Tung, CL; Chen, TJ; Chang, CJ; Lung, FW; Chen, CK; Shiah, IS; Liu, CY; Teng, PR; Chen, KH; Shen, LJ; Cheng, CS; Chang, TP; Li, CF; Chou, CH; Wang, KHT; Fann, CSJ; Wu, JY; Chen, YT; Cheng, ATA
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