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SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes.

Publication ,  Journal Article
Jiang, Y-D; Chang, Y-C; Chiu, Y-F; Chang, T-J; Li, H-Y; Lin, W-H; Yuan, H-Y; Chen, Y-T; Chuang, L-M
Published in: BMC Med Genet
August 25, 2010

BACKGROUND: Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes. METHODS: We genotyped 10 single nucleotide polymorphisms and one microsatellite spanning 34 kb across the SLC2A10 gene in a prospective cohort of 372 diabetic patients. Their association with the development of peripheral arterial disease (PAD) in type 2 diabetic patients was analyzed. RESULTS: At baseline, several common SNPs of SLC2A10 gene were associated with PAD in type 2 diabetic patients. A common haplotype was associated with higher risk of PAD in type 2 diabetic patients (haplotype frequency: 6.3%, P = 0.03; odds ratio [OR]: 14.5; 95% confidence interval [CI]: 1.3- 160.7) at baseline. Over an average follow-up period of 5.7 years, carriers with the risk-conferring haplotype were more likely to develop PAD (P = 0.007; hazard ratio: 6.78; 95% CI: 1.66- 27.6) than were non-carriers. These associations remained significant after adjustment for other risk factors of PAD. CONCLUSION: Our data demonstrate that genetic polymorphism of the SLC2A10 gene is an independent risk factor for PAD in type 2 diabetes.

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Published In

BMC Med Genet

DOI

EISSN

1471-2350

Publication Date

August 25, 2010

Volume

11

Start / End Page

126

Location

England

Related Subject Headings

  • Transforming Growth Factor beta
  • Risk Factors
  • Risk
  • Polymorphism, Single Nucleotide
  • Peripheral Vascular Diseases
  • Odds Ratio
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jiang, Y.-D., Chang, Y.-C., Chiu, Y.-F., Chang, T.-J., Li, H.-Y., Lin, W.-H., … Chuang, L.-M. (2010). SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes. BMC Med Genet, 11, 126. https://doi.org/10.1186/1471-2350-11-126
Jiang, Yi-Der, Yi-Cheng Chang, Yen-Feng Chiu, Tien-Jyun Chang, Hung-Yuan Li, Wen-Hsing Lin, Hsiang-Yu Yuan, Yuan-Tsong Chen, and Lee-Ming Chuang. “SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes.BMC Med Genet 11 (August 25, 2010): 126. https://doi.org/10.1186/1471-2350-11-126.
Jiang Y-D, Chang Y-C, Chiu Y-F, Chang T-J, Li H-Y, Lin W-H, et al. SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes. BMC Med Genet. 2010 Aug 25;11:126.
Jiang, Yi-Der, et al. “SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes.BMC Med Genet, vol. 11, Aug. 2010, p. 126. Pubmed, doi:10.1186/1471-2350-11-126.
Jiang Y-D, Chang Y-C, Chiu Y-F, Chang T-J, Li H-Y, Lin W-H, Yuan H-Y, Chen Y-T, Chuang L-M. SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes. BMC Med Genet. 2010 Aug 25;11:126.
Journal cover image

Published In

BMC Med Genet

DOI

EISSN

1471-2350

Publication Date

August 25, 2010

Volume

11

Start / End Page

126

Location

England

Related Subject Headings

  • Transforming Growth Factor beta
  • Risk Factors
  • Risk
  • Polymorphism, Single Nucleotide
  • Peripheral Vascular Diseases
  • Odds Ratio
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans