Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

Published

Journal Article

AIM: Cytochrome P450 is an important monooxygenase responsible for the metabolism of a large variety of structurally diverse compounds. The aim of this study was to systematically investigate the DNA sequence variations in 14 cytochrome P450 genes relevant to drug metabolism in the Han Chinese population. MATERIALS & METHODS: We sequenced these 14 genes in 23 subjects and determined the allele frequencies. RESULTS: We identified a total of 312 genetic variants, which included 80 (25.6%) novel variants. These novel variants included 67 noncoding variants, four synonymous and nine nonsynonymous variants. Among these variants, an 11-nucleotide insertion in the 3-flanking site of intron 6 in CYP2E1 (c.968-77_-76insGATGGGTGGAT) had the highest allele frequency of 0.565. A total of 16 of these novel variants were predicted to have potential functional consequences; however, among them only c.-1299T>A in CYP2C18 and c.-498C>A in CYP2D6 reached a frequency of 4.9%. CONCLUSIONS: This study establishes a genetic database of cytochrome P450 genes in the Han Chinese population and suggests further genetic diversity throughout this important gene family.

Full Text

Duke Authors

Cited Authors

  • Wang, H-H; Liao, Y-W; Chiang, H-L; Wu, J-Y; Chen, Y-T

Published Date

  • March 2009

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 359 - 374

PubMed ID

  • 19290787

Pubmed Central ID

  • 19290787

Electronic International Standard Serial Number (EISSN)

  • 1744-8042

Digital Object Identifier (DOI)

  • 10.2217/14622416.10.3.359

Language

  • eng

Conference Location

  • England