Medical genetics: a marker for Stevens-Johnson syndrome.

Journal Article

Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.

Duke Authors

Cited Authors

  • Chung, WH; Hung, SI; Hong, HS; Hsih, MS; Yang, LC; Ho, HC; Wu, JY; Chen, YT

Published Date

  • 2004

Published In

  • Nature

Volume / Issue

  • 428 / 6982

Start / End Page

  • 486- -