Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Published
Journal Article
Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-kappaB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.
Full Text
Duke Authors
Cited Authors
- Chan, DA; Kawahara, TLA; Sutphin, PD; Chang, HY; Chi, J-T; Giaccia, AJ
Published Date
- June 2, 2009
Published In
Volume / Issue
- 15 / 6
Start / End Page
- 527 - 538
PubMed ID
- 19477431
Pubmed Central ID
- 19477431
Electronic International Standard Serial Number (EISSN)
- 1878-3686
Digital Object Identifier (DOI)
- 10.1016/j.ccr.2009.04.010
Language
- eng
Conference Location
- United States