Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

Published

Journal Article

Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-kappaB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.

Full Text

Duke Authors

Cited Authors

  • Chan, DA; Kawahara, TLA; Sutphin, PD; Chang, HY; Chi, J-T; Giaccia, AJ

Published Date

  • June 2009

Published In

Volume / Issue

  • 15 / 6

Start / End Page

  • 527 - 538

PubMed ID

  • 19477431

Pubmed Central ID

  • 19477431

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2009.04.010

Language

  • eng