Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-kappaB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.
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Related Subject Headings
- Ribonuclease, Pancreatic
- Procollagen-Proline Dioxygenase
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Neoplasms, Experimental
- Neoplasm Transplantation
- NF-kappa B
- Mice, SCID
- Mice
- Male
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Ribonuclease, Pancreatic
- Procollagen-Proline Dioxygenase
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Neoplasms, Experimental
- Neoplasm Transplantation
- NF-kappa B
- Mice, SCID
- Mice
- Male