Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines.

Journal Article

Overexpression of oncogenes has been associated with the pathogenesis of some human cancers. The ros oncogene, which encodes a putative receptor with tyrosine kinase activity, has been recently shown to be specifically expressed in high levels in human astrocytoma and glioblastoma cell lines. Using transcription mapping analysis, we surveyed 25 primary astrocytomas of all histological grades, including glioblastomas, and failed to demonstrate elevated expression of ros in these tumors. This difference between the cell lines and the primary tumors may be due to dilution of the ros-positive clones by larger populations of ros-negative cells in the primary tumors or to induction of ros oncogene when the tumors are adapted to tissue culture.

Full Text

Duke Authors

Cited Authors

  • Wu, JK; Chikaraishi, DM

Published Date

  • May 15, 1990

Published In

Volume / Issue

  • 50 / 10

Start / End Page

  • 3032 - 3035

PubMed ID

  • 2185878

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States