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Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines.

Publication ,  Journal Article
Wu, JK; Chikaraishi, DM
Published in: Cancer Res
May 15, 1990

Overexpression of oncogenes has been associated with the pathogenesis of some human cancers. The ros oncogene, which encodes a putative receptor with tyrosine kinase activity, has been recently shown to be specifically expressed in high levels in human astrocytoma and glioblastoma cell lines. Using transcription mapping analysis, we surveyed 25 primary astrocytomas of all histological grades, including glioblastomas, and failed to demonstrate elevated expression of ros in these tumors. This difference between the cell lines and the primary tumors may be due to dilution of the ros-positive clones by larger populations of ros-negative cells in the primary tumors or to induction of ros oncogene when the tumors are adapted to tissue culture.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

May 15, 1990

Volume

50

Issue

10

Start / End Page

3032 / 3035

Location

United States

Related Subject Headings

  • Restriction Mapping
  • Receptor Protein-Tyrosine Kinases
  • RNA, Neoplasm
  • RNA, Messenger
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Oncogenes
  • Humans
  • Glioma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, J. K., & Chikaraishi, D. M. (1990). Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. Cancer Res, 50(10), 3032–3035.
Wu, J. K., and D. M. Chikaraishi. “Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines.Cancer Res 50, no. 10 (May 15, 1990): 3032–35.
Wu, J. K., and D. M. Chikaraishi. “Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines.Cancer Res, vol. 50, no. 10, May 1990, pp. 3032–35.
Wu JK, Chikaraishi DM. Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. Cancer Res. 1990 May 15;50(10):3032–3035.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

May 15, 1990

Volume

50

Issue

10

Start / End Page

3032 / 3035

Location

United States

Related Subject Headings

  • Restriction Mapping
  • Receptor Protein-Tyrosine Kinases
  • RNA, Neoplasm
  • RNA, Messenger
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Oncogenes
  • Humans
  • Glioma