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Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

Publication ,  Journal Article
Lewis, EJ; Chikaraishi, DM
Published in: Mol Cell Biol
September 1987

The addition of epidermal growth factor (EGF) to cultures of the rat PCG2 pheochromocytoma cell line increased the level of RNA coding for tyrosine hydroxylase (TH). A region of DNA containing 5'-flanking sequences of the TH gene was fused to a heterologous gene and transfected into a rat anterior pituitary cell line, GH4. The TH gene sequences from +27 to -272 contained information sufficient for the induction of TH by EGF. Two regions within this TH DNA were extensively homologous to the EGF regulatory element of the rat prolactin gene.

Duke Scholars

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

September 1987

Volume

7

Issue

9

Start / End Page

3332 / 3336

Location

United States

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Tumor Cells, Cultured
  • Regulatory Sequences, Nucleic Acid
  • Rats
  • RNA, Messenger
  • Promoter Regions, Genetic
  • Pheochromocytoma
  • Gene Expression Regulation
  • Epidermal Growth Factor
  • Developmental Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lewis, E. J., & Chikaraishi, D. M. (1987). Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. Mol Cell Biol, 7(9), 3332–3336. https://doi.org/10.1128/mcb.7.9.3332-3336.1987
Lewis, E. J., and D. M. Chikaraishi. “Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.Mol Cell Biol 7, no. 9 (September 1987): 3332–36. https://doi.org/10.1128/mcb.7.9.3332-3336.1987.
Lewis EJ, Chikaraishi DM. Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. Mol Cell Biol. 1987 Sep;7(9):3332–6.
Lewis, E. J., and D. M. Chikaraishi. “Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.Mol Cell Biol, vol. 7, no. 9, Sept. 1987, pp. 3332–36. Pubmed, doi:10.1128/mcb.7.9.3332-3336.1987.
Lewis EJ, Chikaraishi DM. Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. Mol Cell Biol. 1987 Sep;7(9):3332–3336.

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

September 1987

Volume

7

Issue

9

Start / End Page

3332 / 3336

Location

United States

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Tumor Cells, Cultured
  • Regulatory Sequences, Nucleic Acid
  • Rats
  • RNA, Messenger
  • Promoter Regions, Genetic
  • Pheochromocytoma
  • Gene Expression Regulation
  • Epidermal Growth Factor
  • Developmental Biology