Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.

Published

Journal Article

This paper reports the design, physicochemical characterization and in vitro cytotoxicity of a thermally responsive chimeric polypeptide (CP), derived from an elastin-like polypeptide (ELP). The CP self-assembles into ~40 nm diameter nanoparticles upon conjugation of multiple copies of doxorubicin (Dox), and displays a nanoparticle-to-aggregate phase transition between 39 and 42 °C in media, a temperature range suitable for mild hyperthermia of solid tumors. The CP-Dox nanoparticle is stable upon dilution to low micromolar concentrations, and is cytotoxic at both 37 and 42 °C. A thermally responsive nanoparticle formulation of Dox may prove to be broadly useful in hyperthermia targeted chemotherapy of a variety of solid tumors.

Full Text

Duke Authors

Cited Authors

  • McDaniel, JR; Macewan, SR; Dewhirst, M; Chilkoti, A

Published Date

  • May 2012

Published In

Volume / Issue

  • 159 / 3

Start / End Page

  • 362 - 367

PubMed ID

  • 22421424

Pubmed Central ID

  • 22421424

Electronic International Standard Serial Number (EISSN)

  • 1873-4995

International Standard Serial Number (ISSN)

  • 0168-3659

Digital Object Identifier (DOI)

  • 10.1016/j.jconrel.2012.02.030

Language

  • eng