Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.

Journal Academic Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, U.S. Gov't, Non-P.H.S.

To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.

Full Text

Duke Authors

Cited Authors

  • Callahan, DJ; Liu, W; Li, X; Dreher, MR; Hassouneh, W; Kim, M; Marszalek, P; Chilkoti, A

Published Date

  • April 11, 2012

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 2165 - 2170

PubMed ID

  • 22417133

Electronic International Standard Serial Number (EISSN)

  • 1530-6992

Digital Object Identifier (DOI)

  • 10.1021/nl300630c

Language

  • eng

Citation Source

  • PubMed