Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.
Journal Article (Journal Article)
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
- Callahan, DJ; Liu, W; Li, X; Dreher, MR; Hassouneh, W; Kim, M; Marszalek, P; Chilkoti, A
- April 2012
Volume / Issue
- 12 / 4
Start / End Page
- 2165 - 2170
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)