Applications of elastin-like polypeptides in tissue engineering.

Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.

Full Text

Duke Authors

Cited Authors

  • Nettles, DL; Chilkoti, A; Setton, LA

Published Date

  • December 30, 2010

Published In

Volume / Issue

  • 62 / 15

Start / End Page

  • 1479 - 1485

PubMed ID

  • 20385185

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2010.04.002

Language

  • eng

Citation Source

  • PubMed