Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.


Journal Article (Review)

Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in 'smart' - stimulus-responsive - peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.

Full Text

Duke Authors

Cited Authors

  • MacEwan, SR; Callahan, DJ; Chilkoti, A

Published Date

  • July 2010

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 793 - 806

PubMed ID

  • 20662649

Pubmed Central ID

  • 20662649

Electronic International Standard Serial Number (EISSN)

  • 1748-6963

International Standard Serial Number (ISSN)

  • 1743-5889

Digital Object Identifier (DOI)

  • 10.2217/nnm.10.50


  • eng