Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.

Journal Article (Review;Journal Article)

Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in 'smart' - stimulus-responsive - peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.

Full Text

Duke Authors

Cited Authors

  • MacEwan, SR; Callahan, DJ; Chilkoti, A

Published Date

  • July 2010

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 793 - 806

PubMed ID

  • 20662649

Pubmed Central ID

  • PMC2963449

Electronic International Standard Serial Number (EISSN)

  • 1748-6963

International Standard Serial Number (ISSN)

  • 1743-5889

Digital Object Identifier (DOI)

  • 10.2217/nnm.10.50


  • eng