Statistical methods for assessing interchangeability of biosimilars.


Journal Article

Unlike traditional small molecule (chemical) drug products, the development of biologic products is very different and variable with respect to the manufacturing process and environmental factors such as light and temperature. The complexity and heterogeneity of the molecular structure, complicated manufacturing process, different analytical methods, and possibility of severe immunogenicity reactions make quantitative evaluation of follow-on biologics a great challenge to both scientific community and regulatory agencies. In this article, we propose a general approach for development of a biosimilarity index based on the concept of reproducibility probability for quantitative evaluation of biosimilarity and interchangeability. The proposed method is robust regardless the biosimilarity criteria used and/or study design employed.

Full Text

Duke Authors

Cited Authors

  • Chow, S-C; Yang, L-Y; Starr, A; Chiu, S-T

Published Date

  • February 10, 2013

Published In

Volume / Issue

  • 32 / 3

Start / End Page

  • 442 - 448

PubMed ID

  • 22899372

Pubmed Central ID

  • 22899372

Electronic International Standard Serial Number (EISSN)

  • 1097-0258

Digital Object Identifier (DOI)

  • 10.1002/sim.5566


  • eng

Conference Location

  • England